High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS

Glycosaminoglycans are an important class of carbohydrates, but pose substantial analytical challenges. Here ToF-SIMS combined with multivariate analysis distinguishes six classes of glycosaminoglycans, including distinguishing heparin samples from different animal sources at a sensitivity as low as...

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Autores principales:	Andrew L. Hook, John Hogwood, Elaine Gray, Barbara Mulloy, Catherine L. R. Merry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c121f4f95c754304b98a4975451b0470
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spelling	oai:doaj.org-article:c121f4f95c754304b98a4975451b04702021-12-02T16:50:20ZHigh sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS10.1038/s42004-021-00506-12399-3669https://doaj.org/article/c121f4f95c754304b98a4975451b04702021-05-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00506-1https://doaj.org/toc/2399-3669Glycosaminoglycans are an important class of carbohydrates, but pose substantial analytical challenges. Here ToF-SIMS combined with multivariate analysis distinguishes six classes of glycosaminoglycans, including distinguishing heparin samples from different animal sources at a sensitivity as low as 0.001 wt%Andrew L. HookJohn HogwoodElaine GrayBarbara MulloyCatherine L. R. MerryNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Andrew L. Hook John Hogwood Elaine Gray Barbara Mulloy Catherine L. R. Merry High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
description	Glycosaminoglycans are an important class of carbohydrates, but pose substantial analytical challenges. Here ToF-SIMS combined with multivariate analysis distinguishes six classes of glycosaminoglycans, including distinguishing heparin samples from different animal sources at a sensitivity as low as 0.001 wt%
format	article
author	Andrew L. Hook John Hogwood Elaine Gray Barbara Mulloy Catherine L. R. Merry
author_facet	Andrew L. Hook John Hogwood Elaine Gray Barbara Mulloy Catherine L. R. Merry
author_sort	Andrew L. Hook
title	High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
title_short	High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
title_full	High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
title_fullStr	High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
title_full_unstemmed	High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS
title_sort	high sensitivity analysis of nanogram quantities of glycosaminoglycans using tof-sims
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c121f4f95c754304b98a4975451b0470
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High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS

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