Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies

Abstract Pre- and post-transplantation anti-MICA antibody detection development are associated with an increased rejection risk and low graft survival. We previously generated HLA class I null HEK-293T using CRISPR/Cas9, while MICA and MICB genes were removed in this study. A panel of 11 cell lines...

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Autores principales: Ji-Ho Jeon, In-Cheol Baek, Cheol-Hwa Hong, Ki Hyun Park, Hyeyoung Lee, Eun-Jee Oh, Tai-Gyu Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c13fc26bf6434a42ab6e2b7ee7419048
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