Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells

There are two technical impediments for using purified Wnt proteins in serum-free stem cell cultures: rapid loss of activity and toxicity of detergents to stem cell self-renewal. Here, the authors show that lipid-stabilized Wnt3a can establish long-term culture of human intestinal and liver organoid...

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Autores principales: Nesrin Tüysüz, Louis van Bloois, Stieneke van den Brink, Harry Begthel, Monique M. A. Verstegen, Luis J. Cruz, Lijian Hui, Luc J. W. van der Laan, Jeroen de Jonge, Robert Vries, Eric Braakman, Enrico Mastrobattista, Jan J. Cornelissen, Hans Clevers, Derk ten Berge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c1491917e9fe4c3fa3f5944fd3318bf1
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https://doaj.org/article/c1491917e9fe4c3fa3f5944fd3318bf1

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