No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.

Antigen presentation by MHC class I molecules requires degradation of epitope source proteins in the cytosol. Although the preeminent role of the proteasome is clearly established, evidence suggesting a significant role for proteasome-independent generation of class I ligands has been reported repea...

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Autores principales: Slobodan Culina, François-Xavier Mauvais, Hsiang-Ting Hsu, Anne Burgevin, Suzanne Guénette, Anna Moser, Peter van Endert
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/c17794ffb1494ec3a8a902f1e3c68dc4
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