No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.
Antigen presentation by MHC class I molecules requires degradation of epitope source proteins in the cytosol. Although the preeminent role of the proteasome is clearly established, evidence suggesting a significant role for proteasome-independent generation of class I ligands has been reported repea...
Guardado en:
Autores principales: | Slobodan Culina, François-Xavier Mauvais, Hsiang-Ting Hsu, Anne Burgevin, Suzanne Guénette, Anna Moser, Peter van Endert |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/c17794ffb1494ec3a8a902f1e3c68dc4 |
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