Conversion of RpoS<sup>−</sup> Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS<sup>+</sup> Improves Their Resistance to Host Defense Barriers
ABSTRACT The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an import...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c1993bec9cbd489da77b1ebb59e7ebb9 |
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