Conversion of RpoS<sup>−</sup> Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS<sup>+</sup> Improves Their Resistance to Host Defense Barriers

Conversion of RpoS<sup>−</sup> Attenuated <named-content content-type="genus-species">Salmonella enterica</named-content> Serovar Typhi Vaccine Strains to RpoS<sup>+</sup> Improves Their Resistance to Host Defense Barriers

ABSTRACT The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an import...

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Autores principales: Whittney N. Burda, Karen E. Brenneman, Amanda Gonzales, Roy Curtiss
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
RASV
RpoS
S. Typhi vaccines
Salmonella
recombinant
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/c1993bec9cbd489da77b1ebb59e7ebb9
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