Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme
Cyclohexadienyl dehydratase (CDT) evolved from a cationic amino acid binding protein ancestor without enzymatic activity (AncCDT-1) via a series of intermediates. Here, the authors combine EPR, X-ray crystallography and MD simulations to study the structural dynamics of these evolutionary intermedia...
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Auteurs principaux: | , , , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
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Accès en ligne: | https://doaj.org/article/c19f20f6641e4d50a18da243f7703954 |
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