Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
Lymphotoxin regulates lymphoid organ architecture and adhesion molecules involved in lymphocyte trafficking. Here the authors show that lymphotoxin produced by regulatory T cells promotes their migration to the draining lymph nodes by engaging its cognate receptor on lymphatic endothelial cells.
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Main Authors: | C. Colin Brinkman, Daiki Iwami, Molly K. Hritzo, Yanbao Xiong, Sarwat Ahmad, Thomas Simon, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
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Subjects: | |
Online Access: | https://doaj.org/article/c1b7c04c5e344820ad62ca3e16a0863c |
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