BALB/c mice deficient in CD4 T cell IL-4Rα expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype.

Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4Rα-deficient mice fail to develop lesions and develop a robust Th1 response. In order to determine the functional...

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Bibliographic Details
Main Authors: Karen J Bryson, Owain R Millington, Thabang Mokgethi, H Adrienne McGachy, Frank Brombacher, James Alexander
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
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Online Access:https://doaj.org/article/c1bcd7b868c747fbbf2c5478bf3bef93
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