Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals

Formation of tertiary C(sp3)-C bonds is a formidable challenge due to steric interactions and low barriers for isomerization of intermediates. Here, the authors show a Ni-catalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary carbon centers.

Guardado en:

Detalles Bibliográficos
Autores principales:	Chuan Zhu, Ze-Yao Liu, Luning Tang, Heng Zhang, Yu-Feng Zhang, Patrick J. Walsh, Chao Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1c1c6877e324880b55b8b6a26de7d25
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c1c1c6877e324880b55b8b6a26de7d25
record_format	dspace
spelling	oai:doaj.org-article:c1c1c6877e324880b55b8b6a26de7d252021-12-02T18:48:04ZMigratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals10.1038/s41467-020-18658-42041-1723https://doaj.org/article/c1c1c6877e324880b55b8b6a26de7d252020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18658-4https://doaj.org/toc/2041-1723Formation of tertiary C(sp3)-C bonds is a formidable challenge due to steric interactions and low barriers for isomerization of intermediates. Here, the authors show a Ni-catalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary carbon centers.Chuan ZhuZe-Yao LiuLuning TangHeng ZhangYu-Feng ZhangPatrick J. WalshChao FengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuan Zhu Ze-Yao Liu Luning Tang Heng Zhang Yu-Feng Zhang Patrick J. Walsh Chao Feng Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
description	Formation of tertiary C(sp3)-C bonds is a formidable challenge due to steric interactions and low barriers for isomerization of intermediates. Here, the authors show a Ni-catalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary carbon centers.
format	article
author	Chuan Zhu Ze-Yao Liu Luning Tang Heng Zhang Yu-Feng Zhang Patrick J. Walsh Chao Feng
author_facet	Chuan Zhu Ze-Yao Liu Luning Tang Heng Zhang Yu-Feng Zhang Patrick J. Walsh Chao Feng
author_sort	Chuan Zhu
title	Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
title_short	Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
title_full	Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
title_fullStr	Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
title_full_unstemmed	Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals
title_sort	migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-c-radicals
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c1c1c6877e324880b55b8b6a26de7d25
work_keys_str_mv	AT chuanzhu migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT zeyaoliu migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT luningtang migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT hengzhang migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT yufengzhang migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT patrickjwalsh migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals AT chaofeng migratoryfunctionalizationofunactivatedalkylbromidesforconstructionofallcarbonquaternarycentersviatransposedtertcradicals
_version_	1718377647839379456

Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals

Ejemplares similares