Design of time-delayed safety switches for CRISPR gene therapy

Abstract CRISPR system is a powerful gene editing tool which has already been reported to address a variety of gene relevant diseases in different cell lines. However, off-target effect and immune response caused by Cas9 remain two fundamental problems. Inspired by previously reported Cas9 self-elim...

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Autor principal: Dashan Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c208778be87c453c8b14d22081acd8d8
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