Design of time-delayed safety switches for CRISPR gene therapy
Abstract CRISPR system is a powerful gene editing tool which has already been reported to address a variety of gene relevant diseases in different cell lines. However, off-target effect and immune response caused by Cas9 remain two fundamental problems. Inspired by previously reported Cas9 self-elim...
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| Formato: | article |
| Lenguaje: | EN |
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/c208778be87c453c8b14d22081acd8d8 |
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