Digital logic circuits in yeast with CRISPR-dCas9 NOR gates

The leakiness of commonly used genetic components can make the construction of complex synthetic circuits difficult. Here the authors construct NOR gate architecture, using dCas9 fused to the chromatin remodeller Mxi1, that can be wired together into complex circuits.

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Auteurs principaux: Miles W. Gander, Justin D. Vrana, William E. Voje, James M. Carothers, Eric Klavins
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Q
Accès en ligne:https://doaj.org/article/c217f5f654de4540a39993619de94545
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