p53 gene targeting by homologous recombination in fish ES cells.

p53 gene targeting by homologous recombination in fish ES cells.

<h4>Background</h4>Gene targeting (GT) provides a powerful tool for the generation of precise genetic alterations in embryonic stem (ES) cells to elucidate gene function and create animal models for human diseases. This technology has, however, been limited to mouse and rat. We have prev...

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Bibliographic Details
Main Authors: Yan Yan, Ni Hong, Tiansheng Chen, Mingyou Li, Tiansu Wang, Guijun Guan, Yongkang Qiao, Songlin Chen, Manfred Schartl, Chang-Ming Li, Yunhan Hong
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/c21a03c8ebd2444db2d449ad5be1534c
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