The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

Skeletal muscle has remarkable adaptive and regenerative capacity. Here the authors show that the transcription factor Prox1 is necessary for maintenance of slow muscle fibre types via activation of NFAT signalling, and for myoblast differentiation via cross-talk with the Notch signalling pathway.

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Autores principales:	Riikka Kivelä, Ida Salmela, Yen Hoang Nguyen, Tatiana V. Petrova, Heikki A. Koistinen, Zoltan Wiener, Kari Alitalo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c23596d197984691a88066f302fb7100
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spelling	oai:doaj.org-article:c23596d197984691a88066f302fb71002021-12-02T15:34:57ZThe transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation10.1038/ncomms131242041-1723https://doaj.org/article/c23596d197984691a88066f302fb71002016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13124https://doaj.org/toc/2041-1723Skeletal muscle has remarkable adaptive and regenerative capacity. Here the authors show that the transcription factor Prox1 is necessary for maintenance of slow muscle fibre types via activation of NFAT signalling, and for myoblast differentiation via cross-talk with the Notch signalling pathway.Riikka KiveläIda SalmelaYen Hoang NguyenTatiana V. PetrovaHeikki A. KoistinenZoltan WienerKari AlitaloNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riikka Kivelä Ida Salmela Yen Hoang Nguyen Tatiana V. Petrova Heikki A. Koistinen Zoltan Wiener Kari Alitalo The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
description	Skeletal muscle has remarkable adaptive and regenerative capacity. Here the authors show that the transcription factor Prox1 is necessary for maintenance of slow muscle fibre types via activation of NFAT signalling, and for myoblast differentiation via cross-talk with the Notch signalling pathway.
format	article
author	Riikka Kivelä Ida Salmela Yen Hoang Nguyen Tatiana V. Petrova Heikki A. Koistinen Zoltan Wiener Kari Alitalo
author_facet	Riikka Kivelä Ida Salmela Yen Hoang Nguyen Tatiana V. Petrova Heikki A. Koistinen Zoltan Wiener Kari Alitalo
author_sort	Riikka Kivelä
title	The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
title_short	The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
title_full	The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
title_fullStr	The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
title_full_unstemmed	The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
title_sort	transcription factor prox1 is essential for satellite cell differentiation and muscle fibre-type regulation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c23596d197984691a88066f302fb7100
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The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

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