Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks

Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks

Abstract A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis. However, pharmacologic anti-androgen...

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Main Authors: Timothy H. Helms, Riley D. Mullins, Jennifer M. Thomas-Ahner, Samuel K. Kulp, Moray J. Campbell, Fabienne Lucas, Nathan Schmidt, Dana M. LeMoine, Surafel Getaneh, Zhiliang Xie, Mitch A. Phelps, Steven K. Clinton, Christopher C. Coss
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/c25b0208e10b4d27952527a2f7974c56
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