Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts.

The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative functional evaluation. To examine the relationship...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Maher A Noureddine, Daniel Menendez, Michelle R Campbell, Omari J Bandele, Monica M Horvath, Xuting Wang, Gary S Pittman, Brian N Chorley, Michael A Resnick, Douglas A Bell
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Acceso en línea:https://doaj.org/article/c25bbce90e3945b88637a8ae0d552b94
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!