A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the ac...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gajanan S Patil, Priyadarshan Kinatukara, Sudipta Mondal, Sakshi Shambhavi, Ketan D Patel, Surabhi Pramanik, Noopur Dubey, Subhash Narasimhan, Murali Krishna Madduri, Biswajit Pal, Rajesh S Gokhale, Rajan Sankaranarayanan
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
fatty acyl-AMP ligases
polyketide synthases
nonribosomal peptide synthetases
coenzyme A
fatty acids
acyl carrier protein
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c2652a9c2f7b4d7a89a1c081a858f05a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/c2652a9c2f7b4d7a89a1c081a858f05a

Ejemplares similares