A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the ac...

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Bibliographic Details
Main Authors: Gajanan S Patil, Priyadarshan Kinatukara, Sudipta Mondal, Sakshi Shambhavi, Ketan D Patel, Surabhi Pramanik, Noopur Dubey, Subhash Narasimhan, Murali Krishna Madduri, Biswajit Pal, Rajesh S Gokhale, Rajan Sankaranarayanan
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
fatty acyl-AMP ligases
polyketide synthases
nonribosomal peptide synthetases
coenzyme A
fatty acids
acyl carrier protein
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/c2652a9c2f7b4d7a89a1c081a858f05a
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