Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease.

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and r...

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Autores principales: Avik Roy, Anamitra Ghosh, Arundhati Jana, Xiaojuan Liu, Saurav Brahmachari, Howard E Gendelman, Kalipada Pahan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/c26709cd0e7346fea36fa0b88f351750
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