The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.

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Detalles Bibliográficos
Autores principales: Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c2bf829fec2b403580972f4e566da03c
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https://doaj.org/article/c2bf829fec2b403580972f4e566da03c

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