The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.

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Autores principales:	Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2bf829fec2b403580972f4e566da03c
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spelling	oai:doaj.org-article:c2bf829fec2b403580972f4e566da03c2021-12-02T14:47:36ZThe BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes10.1038/s41467-020-16441-z2041-1723https://doaj.org/article/c2bf829fec2b403580972f4e566da03c2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16441-zhttps://doaj.org/toc/2041-1723If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.Elias ElInatiAgata P. ZielinskaAfshan McCarthyNada KubikovaValdone MaciulyteShantha MahadevaiahMahesh N. SangrithiObah OjarikreDagan WellsKathy K. NiakanMelina SchuhJames M. A. TurnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
description	If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1 −/− and Msh5 −/− oocytes.
format	article
author	Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner
author_facet	Elias ElInati Agata P. Zielinska Afshan McCarthy Nada Kubikova Valdone Maciulyte Shantha Mahadevaiah Mahesh N. Sangrithi Obah Ojarikre Dagan Wells Kathy K. Niakan Melina Schuh James M. A. Turner
author_sort	Elias ElInati
title	The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
title_short	The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
title_full	The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
title_fullStr	The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
title_full_unstemmed	The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
title_sort	bcl-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c2bf829fec2b403580972f4e566da03c
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The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

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