Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Global profiling of protein–DNA and protein–nucleosome binding affinities using quantitative mass spectrometry

Quantitative mass spectrometry enables the proteome-wide assessment of biomolecular binding affinities. While previous approaches mainly focused on protein–small molecule interactions, the authors here present a method to probe protein–DNA and protein–nucleosome binding affinities at proteome scale....

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Bibliographic Details
Main Authors: Matthew M. Makowski, Cathrin Gräwe, Benjamin M. Foster, Nhuong V. Nguyen, Till Bartke, Michiel Vermeulen
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/c2e2ac02d50d492280b29ec96a5b844c
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