An entropy-based metric for assessing the purity of single cell populations

Single cell RNA-seq is a powerful method to assign cell identity, but the purity of cell clusters arising from this data is not clear. Here the authors present an entropy-based statistic called ROGUE to quantify the purity of cell clusters, and identify subtypes within clusters.

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Autores principales: Baolin Liu, Chenwei Li, Ziyi Li, Dongfang Wang, Xianwen Ren, Zemin Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c2ec1f439bfd4b2a981eb0a38bcf1f51
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