Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Néstor Saiz, Kiah M. Williams, Venkatraman E. Seshan, Anna-Katerina Hadjantonakis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/c2f12aea656245e49a6337f8fa0848fb
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of its size.