Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of i...

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Autores principales:	Néstor Saiz, Kiah M. Williams, Venkatraman E. Seshan, Anna-Katerina Hadjantonakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c2f12aea656245e49a6337f8fa0848fb
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spelling	oai:doaj.org-article:c2f12aea656245e49a6337f8fa0848fb2021-12-02T15:34:30ZAsynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst10.1038/ncomms134632041-1723https://doaj.org/article/c2f12aea656245e49a6337f8fa0848fb2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13463https://doaj.org/toc/2041-1723Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of its size.Néstor SaizKiah M. WilliamsVenkatraman E. SeshanAnna-Katerina HadjantonakisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Néstor Saiz Kiah M. Williams Venkatraman E. Seshan Anna-Katerina Hadjantonakis Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
description	Early embryonic cell fate and lineage specification is tightly regulated in the preimplantation mammalian embryo. Here, the authors quantitatively examine the ratio of epiblast to primitive endoderm lineages in the blastocyst and show composition of the inner cell mass is conserved, independent of its size.
format	article
author	Néstor Saiz Kiah M. Williams Venkatraman E. Seshan Anna-Katerina Hadjantonakis
author_facet	Néstor Saiz Kiah M. Williams Venkatraman E. Seshan Anna-Katerina Hadjantonakis
author_sort	Néstor Saiz
title	Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
title_short	Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
title_full	Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
title_fullStr	Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
title_full_unstemmed	Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
title_sort	asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c2f12aea656245e49a6337f8fa0848fb
work_keys_str_mv	AT nestorsaiz asynchronousfatedecisionsbysinglecellscollectivelyensureconsistentlineagecompositioninthemouseblastocyst AT kiahmwilliams asynchronousfatedecisionsbysinglecellscollectivelyensureconsistentlineagecompositioninthemouseblastocyst AT venkatramaneseshan asynchronousfatedecisionsbysinglecellscollectivelyensureconsistentlineagecompositioninthemouseblastocyst AT annakaterinahadjantonakis asynchronousfatedecisionsbysinglecellscollectivelyensureconsistentlineagecompositioninthemouseblastocyst
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Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst

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