The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation
Caveolae and their major constituent Caveolin-1 (CAV1) play an important role in signalling pathways involved in inflammation, but regulators of CAV1 protein stability are unknown. Here, the authors show that E3 ubiquitin ligase ZNRF1 induces degradation of CAV1 in response to TLR4 activation, and m...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c30b0e30686342fe9db885694ae7780d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c30b0e30686342fe9db885694ae7780d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c30b0e30686342fe9db885694ae7780d2021-12-02T14:42:16ZThe ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation10.1038/ncomms155022041-1723https://doaj.org/article/c30b0e30686342fe9db885694ae7780d2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15502https://doaj.org/toc/2041-1723Caveolae and their major constituent Caveolin-1 (CAV1) play an important role in signalling pathways involved in inflammation, but regulators of CAV1 protein stability are unknown. Here, the authors show that E3 ubiquitin ligase ZNRF1 induces degradation of CAV1 in response to TLR4 activation, and mediates the pro-inflammatory response bothin vitro and in vivo.Chih-Yuan LeeTing-Yu LaiMeng-Kun TsaiYung-Chi ChangYu-Hsin HoI-Shing YuTzu-Wen YehChih-Chang ChouYou-Sheng LinToby LawrenceLi-Chung HsuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chih-Yuan Lee Ting-Yu Lai Meng-Kun Tsai Yung-Chi Chang Yu-Hsin Ho I-Shing Yu Tzu-Wen Yeh Chih-Chang Chou You-Sheng Lin Toby Lawrence Li-Chung Hsu The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| description |
Caveolae and their major constituent Caveolin-1 (CAV1) play an important role in signalling pathways involved in inflammation, but regulators of CAV1 protein stability are unknown. Here, the authors show that E3 ubiquitin ligase ZNRF1 induces degradation of CAV1 in response to TLR4 activation, and mediates the pro-inflammatory response bothin vitro and in vivo. |
| format |
article |
| author |
Chih-Yuan Lee Ting-Yu Lai Meng-Kun Tsai Yung-Chi Chang Yu-Hsin Ho I-Shing Yu Tzu-Wen Yeh Chih-Chang Chou You-Sheng Lin Toby Lawrence Li-Chung Hsu |
| author_facet |
Chih-Yuan Lee Ting-Yu Lai Meng-Kun Tsai Yung-Chi Chang Yu-Hsin Ho I-Shing Yu Tzu-Wen Yeh Chih-Chang Chou You-Sheng Lin Toby Lawrence Li-Chung Hsu |
| author_sort |
Chih-Yuan Lee |
| title |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| title_short |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| title_full |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| title_fullStr |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| title_full_unstemmed |
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| title_sort |
ubiquitin ligase znrf1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/c30b0e30686342fe9db885694ae7780d |
| work_keys_str_mv |
AT chihyuanlee theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tingyulai theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT mengkuntsai theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT yungchichang theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT yuhsinho theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT ishingyu theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tzuwenyeh theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT chihchangchou theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT youshenglin theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tobylawrence theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT lichunghsu theubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT chihyuanlee ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tingyulai ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT mengkuntsai ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT yungchichang ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT yuhsinho ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT ishingyu ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tzuwenyeh ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT chihchangchou ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT youshenglin ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT tobylawrence ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation AT lichunghsu ubiquitinligaseznrf1promotescaveolin1ubiquitinationanddegradationtomodulateinflammation |
| _version_ |
1718389777027301376 |