Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the disorders, despite being caused by the same protein. While the vulnerabilit...

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Autores principales: Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/c31617df76534fe29fe2eb777ce0b3f4
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