Natural product fragment combination to performance-diverse pseudo-natural products
Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the pheno...
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Nature Portfolio
2021
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oai:doaj.org-article:c324981d1dd847a2877255197701b2a32021-12-02T16:35:53ZNatural product fragment combination to performance-diverse pseudo-natural products10.1038/s41467-021-22174-42041-1723https://doaj.org/article/c324981d1dd847a2877255197701b2a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22174-4https://doaj.org/toc/2041-1723Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.Michael GrigalunasAnnina BurhopSarah ZinkenAxel PahlJosé-Manuel GallyNiklas WildYannik MantelSonja SieversDaniel J. FoleyRebecca ScheelCarsten StrohmannAndrey P. AntonchickHerbert WaldmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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Science Q Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann Natural product fragment combination to performance-diverse pseudo-natural products |
description |
Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments. |
format |
article |
author |
Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann |
author_facet |
Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann |
author_sort |
Michael Grigalunas |
title |
Natural product fragment combination to performance-diverse pseudo-natural products |
title_short |
Natural product fragment combination to performance-diverse pseudo-natural products |
title_full |
Natural product fragment combination to performance-diverse pseudo-natural products |
title_fullStr |
Natural product fragment combination to performance-diverse pseudo-natural products |
title_full_unstemmed |
Natural product fragment combination to performance-diverse pseudo-natural products |
title_sort |
natural product fragment combination to performance-diverse pseudo-natural products |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/c324981d1dd847a2877255197701b2a3 |
work_keys_str_mv |
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1718383716919672832 |