Natural product fragment combination to performance-diverse pseudo-natural products

Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the pheno...

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Autores principales:	Michael Grigalunas, Annina Burhop, Sarah Zinken, Axel Pahl, José-Manuel Gally, Niklas Wild, Yannik Mantel, Sonja Sievers, Daniel J. Foley, Rebecca Scheel, Carsten Strohmann, Andrey P. Antonchick, Herbert Waldmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c324981d1dd847a2877255197701b2a3
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spelling	oai:doaj.org-article:c324981d1dd847a2877255197701b2a32021-12-02T16:35:53ZNatural product fragment combination to performance-diverse pseudo-natural products10.1038/s41467-021-22174-42041-1723https://doaj.org/article/c324981d1dd847a2877255197701b2a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22174-4https://doaj.org/toc/2041-1723Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.Michael GrigalunasAnnina BurhopSarah ZinkenAxel PahlJosé-Manuel GallyNiklas WildYannik MantelSonja SieversDaniel J. FoleyRebecca ScheelCarsten StrohmannAndrey P. AntonchickHerbert WaldmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann Natural product fragment combination to performance-diverse pseudo-natural products
description	Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.
format	article
author	Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann
author_facet	Michael Grigalunas Annina Burhop Sarah Zinken Axel Pahl José-Manuel Gally Niklas Wild Yannik Mantel Sonja Sievers Daniel J. Foley Rebecca Scheel Carsten Strohmann Andrey P. Antonchick Herbert Waldmann
author_sort	Michael Grigalunas
title	Natural product fragment combination to performance-diverse pseudo-natural products
title_short	Natural product fragment combination to performance-diverse pseudo-natural products
title_full	Natural product fragment combination to performance-diverse pseudo-natural products
title_fullStr	Natural product fragment combination to performance-diverse pseudo-natural products
title_full_unstemmed	Natural product fragment combination to performance-diverse pseudo-natural products
title_sort	natural product fragment combination to performance-diverse pseudo-natural products
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c324981d1dd847a2877255197701b2a3
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Natural product fragment combination to performance-diverse pseudo-natural products

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