Natural product fragment combination to performance-diverse pseudo-natural products

Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the pheno...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Michael Grigalunas, Annina Burhop, Sarah Zinken, Axel Pahl, José-Manuel Gally, Niklas Wild, Yannik Mantel, Sonja Sievers, Daniel J. Foley, Rebecca Scheel, Carsten Strohmann, Andrey P. Antonchick, Herbert Waldmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/c324981d1dd847a2877255197701b2a3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c324981d1dd847a2877255197701b2a3
record_format dspace
spelling oai:doaj.org-article:c324981d1dd847a2877255197701b2a32021-12-02T16:35:53ZNatural product fragment combination to performance-diverse pseudo-natural products10.1038/s41467-021-22174-42041-1723https://doaj.org/article/c324981d1dd847a2877255197701b2a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22174-4https://doaj.org/toc/2041-1723Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.Michael GrigalunasAnnina BurhopSarah ZinkenAxel PahlJosé-Manuel GallyNiklas WildYannik MantelSonja SieversDaniel J. FoleyRebecca ScheelCarsten StrohmannAndrey P. AntonchickHerbert WaldmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michael Grigalunas
Annina Burhop
Sarah Zinken
Axel Pahl
José-Manuel Gally
Niklas Wild
Yannik Mantel
Sonja Sievers
Daniel J. Foley
Rebecca Scheel
Carsten Strohmann
Andrey P. Antonchick
Herbert Waldmann
Natural product fragment combination to performance-diverse pseudo-natural products
description Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.
format article
author Michael Grigalunas
Annina Burhop
Sarah Zinken
Axel Pahl
José-Manuel Gally
Niklas Wild
Yannik Mantel
Sonja Sievers
Daniel J. Foley
Rebecca Scheel
Carsten Strohmann
Andrey P. Antonchick
Herbert Waldmann
author_facet Michael Grigalunas
Annina Burhop
Sarah Zinken
Axel Pahl
José-Manuel Gally
Niklas Wild
Yannik Mantel
Sonja Sievers
Daniel J. Foley
Rebecca Scheel
Carsten Strohmann
Andrey P. Antonchick
Herbert Waldmann
author_sort Michael Grigalunas
title Natural product fragment combination to performance-diverse pseudo-natural products
title_short Natural product fragment combination to performance-diverse pseudo-natural products
title_full Natural product fragment combination to performance-diverse pseudo-natural products
title_fullStr Natural product fragment combination to performance-diverse pseudo-natural products
title_full_unstemmed Natural product fragment combination to performance-diverse pseudo-natural products
title_sort natural product fragment combination to performance-diverse pseudo-natural products
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c324981d1dd847a2877255197701b2a3
work_keys_str_mv AT michaelgrigalunas naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT anninaburhop naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT sarahzinken naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT axelpahl naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT josemanuelgally naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT niklaswild naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT yannikmantel naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT sonjasievers naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT danieljfoley naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT rebeccascheel naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT carstenstrohmann naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT andreypantonchick naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
AT herbertwaldmann naturalproductfragmentcombinationtoperformancediversepseudonaturalproducts
_version_ 1718383716919672832