Bioluminescence imaging of G protein-coupled receptor activation in living mice

G protein-coupled receptors are involved in numerous physiological functions, thus, they represent potential pharmaceutical targets. Here Kono et al. describe a new mouse model to image GPCR activation in real-time by exploiting firefly split luciferase fragment complementation that can be detected...

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Autores principales:	Mari Kono, Elizabeth G. Conlon, Samantha Y. Lux, Keisuke Yanagida, Timothy Hla, Richard L. Proia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c32511cc563843f48d30e2af1c4c9730
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spelling	oai:doaj.org-article:c32511cc563843f48d30e2af1c4c97302021-12-02T14:43:00ZBioluminescence imaging of G protein-coupled receptor activation in living mice10.1038/s41467-017-01340-72041-1723https://doaj.org/article/c32511cc563843f48d30e2af1c4c97302017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01340-7https://doaj.org/toc/2041-1723G protein-coupled receptors are involved in numerous physiological functions, thus, they represent potential pharmaceutical targets. Here Kono et al. describe a new mouse model to image GPCR activation in real-time by exploiting firefly split luciferase fragment complementation that can be detected by bioluminescence imaging.Mari KonoElizabeth G. ConlonSamantha Y. LuxKeisuke YanagidaTimothy HlaRichard L. ProiaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mari Kono Elizabeth G. Conlon Samantha Y. Lux Keisuke Yanagida Timothy Hla Richard L. Proia Bioluminescence imaging of G protein-coupled receptor activation in living mice
description	G protein-coupled receptors are involved in numerous physiological functions, thus, they represent potential pharmaceutical targets. Here Kono et al. describe a new mouse model to image GPCR activation in real-time by exploiting firefly split luciferase fragment complementation that can be detected by bioluminescence imaging.
format	article
author	Mari Kono Elizabeth G. Conlon Samantha Y. Lux Keisuke Yanagida Timothy Hla Richard L. Proia
author_facet	Mari Kono Elizabeth G. Conlon Samantha Y. Lux Keisuke Yanagida Timothy Hla Richard L. Proia
author_sort	Mari Kono
title	Bioluminescence imaging of G protein-coupled receptor activation in living mice
title_short	Bioluminescence imaging of G protein-coupled receptor activation in living mice
title_full	Bioluminescence imaging of G protein-coupled receptor activation in living mice
title_fullStr	Bioluminescence imaging of G protein-coupled receptor activation in living mice
title_full_unstemmed	Bioluminescence imaging of G protein-coupled receptor activation in living mice
title_sort	bioluminescence imaging of g protein-coupled receptor activation in living mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c32511cc563843f48d30e2af1c4c9730
work_keys_str_mv	AT marikono bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice AT elizabethgconlon bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice AT samanthaylux bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice AT keisukeyanagida bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice AT timothyhla bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice AT richardlproia bioluminescenceimagingofgproteincoupledreceptoractivationinlivingmice
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Bioluminescence imaging of G protein-coupled receptor activation in living mice

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