Evaluation of bisphenylthiazoles as a promising class for combating multidrug-resistant fungal infections

To minimize the intrinsic toxicity of the antibacterial agent hydrazinyloxadiazole 1, the hydrazine moiety was replaced with ethylenediamine (compound 7). This replacement generated a potent antifungal agent with no antibacterial activity. Notably, use of a 1,2-diaminocyclohexane moiety, as a confor...

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Auteurs principaux: Mohamed Hagras, Nader S. Abutaleb, Ahmed M. Sayed, Ehab A. Salama, Mohamed N. Seleem, Abdelrahman S. Mayhoub
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
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R
Q
Accès en ligne:https://doaj.org/article/c32c17df284e4424a4ae463cb4b0531e
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