A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease

Abstract Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such a...

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Autores principales:	Christophe Barba, Bérengère Benoit, Emilie Bres, Stéphanie Chanon, Aurélie Vieille-Marchiset, Claudie Pinteur, Sandra Pesenti, Griet Glorieux, Cécile Picard, Denis Fouque, Christophe O. Soulage, Laetitia Koppe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c3311138d3da4257aad3708803e12510
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spelling	oai:doaj.org-article:c3311138d3da4257aad3708803e125102021-12-02T19:16:59ZA low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease10.1038/s41598-021-98718-x2045-2322https://doaj.org/article/c3311138d3da4257aad3708803e125102021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98718-xhttps://doaj.org/toc/2045-2322Abstract Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition.Christophe BarbaBérengère BenoitEmilie BresStéphanie ChanonAurélie Vieille-MarchisetClaudie PinteurSandra PesentiGriet GlorieuxCécile PicardDenis FouqueChristophe O. SoulageLaetitia KoppeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christophe Barba Bérengère Benoit Emilie Bres Stéphanie Chanon Aurélie Vieille-Marchiset Claudie Pinteur Sandra Pesenti Griet Glorieux Cécile Picard Denis Fouque Christophe O. Soulage Laetitia Koppe A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
description	Abstract Despite decades of use of low protein diets (LPD) in the management of chronic kidney disease (CKD), their mechanisms of action are unclear. A reduced production of uremic toxins could contribute to the benefits of LPDs. Aromatic amino-acids (AA) are precursors of major uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS). We hypothesize that a low aromatic amino acid diet (LA-AAD, namely a low intake of tyrosine, tryptophan and phenylalanine) while being normoproteic, could be as effective as a LPD, through the decreased production of uremic toxins. Kidney failure was chemically induced in mice with a diet containing 0.25% (w/w) of adenine. Mice received three different diets for six weeks: normoproteic diet (NPD: 14.7% proteins, aromatic AAs 0.019%), LPD (5% proteins, aromatic AAs 0.007%) and LA-AAD (14% proteins, aromatic AAs 0.007%). Both LPD and LA-AAD significantly reduced proteinuria, kidney fibrosis and inflammation. While LPD only slightly decreased plasma free PCS and free IS compared to NPD; free fractions of both compounds were significantly decreased by LA-AAD. These results suggest that a LA-AAD confers similar benefits of a LPD in delaying the progression of CKD through a reduction in some key uremic toxins production (such as PCS and IS), with a lower risk of malnutrition.
format	article
author	Christophe Barba Bérengère Benoit Emilie Bres Stéphanie Chanon Aurélie Vieille-Marchiset Claudie Pinteur Sandra Pesenti Griet Glorieux Cécile Picard Denis Fouque Christophe O. Soulage Laetitia Koppe
author_facet	Christophe Barba Bérengère Benoit Emilie Bres Stéphanie Chanon Aurélie Vieille-Marchiset Claudie Pinteur Sandra Pesenti Griet Glorieux Cécile Picard Denis Fouque Christophe O. Soulage Laetitia Koppe
author_sort	Christophe Barba
title	A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_short	A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_full	A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_fullStr	A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_full_unstemmed	A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
title_sort	low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c3311138d3da4257aad3708803e12510
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A low aromatic amino-acid diet improves renal function and prevent kidney fibrosis in mice with chronic kidney disease

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