Systematic CRISPR-Cas9-Mediated Modifications of <italic toggle="yes">Plasmodium yoelii</italic> ApiAP2 Genes Reveal Functional Insights into Parasite Development

Systematic CRISPR-Cas9-Mediated Modifications of <italic toggle="yes">Plasmodium yoelii</italic> ApiAP2 Genes Reveal Functional Insights into Parasite Development

ABSTRACT Malaria parasites have a complex life cycle with multiple developmental stages in mosquito and vertebrate hosts, and different developmental stages express unique sets of genes. Unexpectedly, many transcription factors (TFs) commonly found in eukaryotic organisms are absent in malaria paras...

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Bibliographic Details
Main Authors: Cui Zhang, Zhenkui Li, Huiting Cui, Yuanyuan Jiang, Zhenke Yang, Xu Wang, Han Gao, Cong Liu, Shujia Zhang, Xin-zhuan Su, Jing Yuan
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
genetic modification
malaria
mice
mosquito
transcription
Microbiology
QR1-502
Online Access:https://doaj.org/article/c3396187e2ae4c8c80ba3e40d5ba20f6
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