Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal cell loss. Recently, dysregulation of intracellular Ca2+ homeostasis has been suggested as a common proximal cause of neural dysfunction in AD. Here, we investigated (1) the pathogenic role of des...

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Autores principales: Yoshihide Nakamura, Takeshi Yamamoto, Xiaojuan Xu, Shigeki Kobayashi, Shinji Tanaka, Masaki Tamitani, Takashi Saito, Takaomi C. Saido, Masafumi Yano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c36d9860014d45d09b54d09dfaf5dbb2
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