Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or dec...

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Autores principales: Dibyadeep Datta, Shannon N. Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P. Mecca, Barbara S. Slusher, Angus C. Nairn, Amy F. T. Arnsten
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/c3772190e75c4cda940b9539cf4e6655
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