Chlorophyllin Inhibits Mammalian Thioredoxin Reductase 1 and Triggers Cancer Cell Death

Chlorophyllin Inhibits Mammalian Thioredoxin Reductase 1 and Triggers Cancer Cell Death

Food colorants are widely used by humans in food production and preparation; however, their potential toxicity requires an in-depth analysis. In this study, five out of 15 commercial food colorants, namely, lutein, betanin, caramel, crocin and chlorophyll, significantly inhibited wild type selenopro...

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Bibliographic Details
Main Authors: Shibo Sun, Yici Zhang, Weiping Xu, Yue Zhang, Rui Yang, Jianli Guo, Shui Guan, Qiang Ma, Kun Ma, Jianqiang Xu
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
food colorants
thioredoxin reductase
chlorophyllin
cell death
selenocysteine
SecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins)
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/c3b4f96c78ed4884a071755cd3eea1c3
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