A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.

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Autores principales:	Junlin Wang, Yanan Zhang, Huanhuan Liu, Yong Shang, Linjun Zhou, Penglin Wei, Wen-Bing Yin, Zixin Deng, Xudong Qu, Qianghui Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3b8f0efe137499a839f5836ca824b91
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spelling	oai:doaj.org-article:c3b8f0efe137499a839f5836ca824b912021-12-02T15:35:55ZA biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids10.1038/s41467-019-11344-02041-1723https://doaj.org/article/c3b8f0efe137499a839f5836ca824b912019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11344-0https://doaj.org/toc/2041-1723C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.Junlin WangYanan ZhangHuanhuan LiuYong ShangLinjun ZhouPenglin WeiWen-Bing YinZixin DengXudong QuQianghui ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
description	C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.
format	article
author	Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou
author_facet	Junlin Wang Yanan Zhang Huanhuan Liu Yong Shang Linjun Zhou Penglin Wei Wen-Bing Yin Zixin Deng Xudong Qu Qianghui Zhou
author_sort	Junlin Wang
title	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_short	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_full	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_fullStr	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_full_unstemmed	A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids
title_sort	biocatalytic hydroxylation-enabled unified approach to c19-hydroxylated steroids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c3b8f0efe137499a839f5836ca824b91
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A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

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