The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that ca...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a

Ejemplares similares