The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that ca...

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Autores principales:	Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
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spelling	oai:doaj.org-article:c3c84960b35344d79ec192d4954f0d3a2021-12-02T14:35:50ZThe mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis10.1038/s41467-018-07858-82041-1723https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07858-8https://doaj.org/toc/2041-1723The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that canonical PI3K/Akt signalling is dispensable.Hannah V. WoodcockJessica D. EleyDelphine GuillotinManuela PlatéCarmel B. NanthakumarMatteo MartufiSimon PeaceGerard JobertyDaniel PoeckelRobert B. GoodAdam R. TaylorNico ZinnMatthew ReddingEllen J. FortyRobert E. HyndsCharles SwantonMorten KarsdalToby M. MaherAndrew FisherGiovanna BergaminiRichard P. MarshallAndy D. BlanchardPaul F. MercerRachel C. ChambersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah V. Woodcock Jessica D. Eley Delphine Guillotin Manuela Platé Carmel B. Nanthakumar Matteo Martufi Simon Peace Gerard Joberty Daniel Poeckel Robert B. Good Adam R. Taylor Nico Zinn Matthew Redding Ellen J. Forty Robert E. Hynds Charles Swanton Morten Karsdal Toby M. Maher Andrew Fisher Giovanna Bergamini Richard P. Marshall Andy D. Blanchard Paul F. Mercer Rachel C. Chambers The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
description	The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that canonical PI3K/Akt signalling is dispensable.
format	article
author	Hannah V. Woodcock Jessica D. Eley Delphine Guillotin Manuela Platé Carmel B. Nanthakumar Matteo Martufi Simon Peace Gerard Joberty Daniel Poeckel Robert B. Good Adam R. Taylor Nico Zinn Matthew Redding Ellen J. Forty Robert E. Hynds Charles Swanton Morten Karsdal Toby M. Maher Andrew Fisher Giovanna Bergamini Richard P. Marshall Andy D. Blanchard Paul F. Mercer Rachel C. Chambers
author_facet	Hannah V. Woodcock Jessica D. Eley Delphine Guillotin Manuela Platé Carmel B. Nanthakumar Matteo Martufi Simon Peace Gerard Joberty Daniel Poeckel Robert B. Good Adam R. Taylor Nico Zinn Matthew Redding Ellen J. Forty Robert E. Hynds Charles Swanton Morten Karsdal Toby M. Maher Andrew Fisher Giovanna Bergamini Richard P. Marshall Andy D. Blanchard Paul F. Mercer Rachel C. Chambers
author_sort	Hannah V. Woodcock
title	The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
title_short	The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
title_full	The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
title_fullStr	The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
title_full_unstemmed	The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
title_sort	mtorc1/4e-bp1 axis represents a critical signaling node during fibrogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
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The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

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