The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that ca...

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Autores principales: Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
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