Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macr...

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Autores principales: Qunfeng Luo, Youqi Tao, Wangjian Sheng, Jingxia Lu, Huan Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c3df2b6ef44148c49531f577004f9225
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