Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macr...

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Autores principales:	Qunfeng Luo, Youqi Tao, Wangjian Sheng, Jingxia Lu, Huan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3df2b6ef44148c49531f577004f9225
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spelling	oai:doaj.org-article:c3df2b6ef44148c49531f577004f92252021-12-02T17:31:22ZDinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization10.1038/s41467-018-08010-22041-1723https://doaj.org/article/c3df2b6ef44148c49531f577004f92252019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08010-2https://doaj.org/toc/2041-1723The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macrocycles.Qunfeng LuoYouqi TaoWangjian ShengJingxia LuHuan WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
description	The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macrocycles.
format	article
author	Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang
author_facet	Qunfeng Luo Youqi Tao Wangjian Sheng Jingxia Lu Huan Wang
author_sort	Qunfeng Luo
title	Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
title_short	Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
title_full	Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
title_fullStr	Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
title_full_unstemmed	Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
title_sort	dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c3df2b6ef44148c49531f577004f9225
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Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

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