Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

It is unclear how removal of axon debris and initiation of axon regeneration following nerve injury is co-regulated. In this study, the authors show that the extracellular domain (ECD) of the engulfment receptor, CED-1, functions as an adhesion molecule to promote axonal regeneration after injury, i...

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Autores principales:	Hui Chiu, Yan Zou, Nobuko Suzuki, Yi-Wen Hsieh, Chiou-Fen Chuang, Yi-Chun Wu, Chieh Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c3e36acc10ce4ff3b78d4f3dfb2f6782
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spelling	oai:doaj.org-article:c3e36acc10ce4ff3b78d4f3dfb2f67822021-12-02T17:32:00ZEngulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-110.1038/s41467-018-07291-x2041-1723https://doaj.org/article/c3e36acc10ce4ff3b78d4f3dfb2f67822018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07291-xhttps://doaj.org/toc/2041-1723It is unclear how removal of axon debris and initiation of axon regeneration following nerve injury is co-regulated. In this study, the authors show that the extracellular domain (ECD) of the engulfment receptor, CED-1, functions as an adhesion molecule to promote axonal regeneration after injury, independent of its function in phagocytosisHui ChiuYan ZouNobuko SuzukiYi-Wen HsiehChiou-Fen ChuangYi-Chun WuChieh ChangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Chiu Yan Zou Nobuko Suzuki Yi-Wen Hsieh Chiou-Fen Chuang Yi-Chun Wu Chieh Chang Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
description	It is unclear how removal of axon debris and initiation of axon regeneration following nerve injury is co-regulated. In this study, the authors show that the extracellular domain (ECD) of the engulfment receptor, CED-1, functions as an adhesion molecule to promote axonal regeneration after injury, independent of its function in phagocytosis
format	article
author	Hui Chiu Yan Zou Nobuko Suzuki Yi-Wen Hsieh Chiou-Fen Chuang Yi-Chun Wu Chieh Chang
author_facet	Hui Chiu Yan Zou Nobuko Suzuki Yi-Wen Hsieh Chiou-Fen Chuang Yi-Chun Wu Chieh Chang
author_sort	Hui Chiu
title	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
title_short	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
title_full	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
title_fullStr	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
title_full_unstemmed	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
title_sort	engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of ced-1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c3e36acc10ce4ff3b78d4f3dfb2f6782
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Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

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