β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cel...

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Main Authors:	Tatiana Omelchenko, Alan Hall, Kathryn V. Anderson
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf2
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spelling	oai:doaj.org-article:c41443325cb943e09e9d7b45cae2bbf22021-12-02T16:56:33Zβ-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo10.1038/s41467-020-19889-12041-1723https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19889-1https://doaj.org/toc/2041-1723Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cells due to defective cell protrusions.Tatiana OmelchenkoAlan HallKathryn V. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatiana Omelchenko Alan Hall Kathryn V. Anderson β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
description	Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cells due to defective cell protrusions.
format	article
author	Tatiana Omelchenko Alan Hall Kathryn V. Anderson
author_facet	Tatiana Omelchenko Alan Hall Kathryn V. Anderson
author_sort	Tatiana Omelchenko
title	β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_short	β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_full	β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_fullStr	β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_full_unstemmed	β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_sort	β-pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf2
work_keys_str_mv	AT tatianaomelchenko bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo AT alanhall bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo AT kathrynvanderson bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo
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β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

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