β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cel...

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Auteurs principaux: Tatiana Omelchenko, Alan Hall, Kathryn V. Anderson
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf2
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spelling oai:doaj.org-article:c41443325cb943e09e9d7b45cae2bbf22021-12-02T16:56:33Zβ-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo10.1038/s41467-020-19889-12041-1723https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19889-1https://doaj.org/toc/2041-1723Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cells due to defective cell protrusions.Tatiana OmelchenkoAlan HallKathryn V. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tatiana Omelchenko
Alan Hall
Kathryn V. Anderson
β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
description Mesodermal directional cell migration is needed to establish body plan but how this is regulated is unclear. Here, the authors show that loss of the guanine nucleotide exchange factor for Rac1 and Cdc42, β-Pix, at mouse gastrulation disrupts the orderly, collective anterior migration of mesoderm cells due to defective cell protrusions.
format article
author Tatiana Omelchenko
Alan Hall
Kathryn V. Anderson
author_facet Tatiana Omelchenko
Alan Hall
Kathryn V. Anderson
author_sort Tatiana Omelchenko
title β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_short β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_full β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_fullStr β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_full_unstemmed β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
title_sort β-pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c41443325cb943e09e9d7b45cae2bbf2
work_keys_str_mv AT tatianaomelchenko bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo
AT alanhall bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo
AT kathrynvanderson bpixdependentcellularprotrusionspropelcollectivemesodermmigrationinthemouseembryo
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