Programming mRNA decay to modulate synthetic circuit resource allocation

Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.

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Detalles Bibliográficos
Autores principales: Ophelia S. Venturelli, Mika Tei, Stefan Bauer, Leanne Jade G. Chan, Christopher J. Petzold, Adam P Arkin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c
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Descripción
Sumario:Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.