Programming mRNA decay to modulate synthetic circuit resource allocation

Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.

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Autores principales: Ophelia S. Venturelli, Mika Tei, Stefan Bauer, Leanne Jade G. Chan, Christopher J. Petzold, Adam P Arkin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
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Acceso en línea:https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c
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spelling oai:doaj.org-article:c43786f35a0d4d08ac93c75c2b65d83c2021-12-02T14:41:10ZProgramming mRNA decay to modulate synthetic circuit resource allocation10.1038/ncomms151282041-1723https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15128https://doaj.org/toc/2041-1723Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.Ophelia S. VenturelliMika TeiStefan BauerLeanne Jade G. ChanChristopher J. PetzoldAdam P ArkinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ophelia S. Venturelli
Mika Tei
Stefan Bauer
Leanne Jade G. Chan
Christopher J. Petzold
Adam P Arkin
Programming mRNA decay to modulate synthetic circuit resource allocation
description Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated.
format article
author Ophelia S. Venturelli
Mika Tei
Stefan Bauer
Leanne Jade G. Chan
Christopher J. Petzold
Adam P Arkin
author_facet Ophelia S. Venturelli
Mika Tei
Stefan Bauer
Leanne Jade G. Chan
Christopher J. Petzold
Adam P Arkin
author_sort Ophelia S. Venturelli
title Programming mRNA decay to modulate synthetic circuit resource allocation
title_short Programming mRNA decay to modulate synthetic circuit resource allocation
title_full Programming mRNA decay to modulate synthetic circuit resource allocation
title_fullStr Programming mRNA decay to modulate synthetic circuit resource allocation
title_full_unstemmed Programming mRNA decay to modulate synthetic circuit resource allocation
title_sort programming mrna decay to modulate synthetic circuit resource allocation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c43786f35a0d4d08ac93c75c2b65d83c
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