CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge to researchers. Here the authors fuse CtIP to Cas9 to stimulate recombination at target loci.

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Autores principales: M. Charpentier, A. H. Y. Khedher, S. Menoret, A. Brion, K. Lamribet, E. Dardillac, C. Boix, L. Perrouault, L. Tesson, S. Geny, A. De Cian, J. M. Itier, I. Anegon, B. Lopez, C. Giovannangeli, J. P. Concordet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/c444707298f741f68a4178c901271db6
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spelling oai:doaj.org-article:c444707298f741f68a4178c901271db62021-12-02T17:32:48ZCtIP fusion to Cas9 enhances transgene integration by homology-dependent repair10.1038/s41467-018-03475-72041-1723https://doaj.org/article/c444707298f741f68a4178c901271db62018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03475-7https://doaj.org/toc/2041-1723The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge to researchers. Here the authors fuse CtIP to Cas9 to stimulate recombination at target loci.M. CharpentierA. H. Y. KhedherS. MenoretA. BrionK. LamribetE. DardillacC. BoixL. PerrouaultL. TessonS. GenyA. De CianJ. M. ItierI. AnegonB. LopezC. GiovannangeliJ. P. ConcordetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
M. Charpentier
A. H. Y. Khedher
S. Menoret
A. Brion
K. Lamribet
E. Dardillac
C. Boix
L. Perrouault
L. Tesson
S. Geny
A. De Cian
J. M. Itier
I. Anegon
B. Lopez
C. Giovannangeli
J. P. Concordet
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
description The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge to researchers. Here the authors fuse CtIP to Cas9 to stimulate recombination at target loci.
format article
author M. Charpentier
A. H. Y. Khedher
S. Menoret
A. Brion
K. Lamribet
E. Dardillac
C. Boix
L. Perrouault
L. Tesson
S. Geny
A. De Cian
J. M. Itier
I. Anegon
B. Lopez
C. Giovannangeli
J. P. Concordet
author_facet M. Charpentier
A. H. Y. Khedher
S. Menoret
A. Brion
K. Lamribet
E. Dardillac
C. Boix
L. Perrouault
L. Tesson
S. Geny
A. De Cian
J. M. Itier
I. Anegon
B. Lopez
C. Giovannangeli
J. P. Concordet
author_sort M. Charpentier
title CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
title_short CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
title_full CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
title_fullStr CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
title_full_unstemmed CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
title_sort ctip fusion to cas9 enhances transgene integration by homology-dependent repair
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c444707298f741f68a4178c901271db6
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