The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models

Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly valid, these models have major limitations related t...

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Détails bibliographiques
Auteurs principaux: Rachel Kelly, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Tommy Patton, Declan P. McKernan, Eilís Dowd
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
AAV
Accès en ligne:https://doaj.org/article/c447a4e33b7344ddb7f816064af2a6e0
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