The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models

Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly valid, these models have major limitations related t...

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Autores principales: Rachel Kelly, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Tommy Patton, Declan P. McKernan, Eilís Dowd
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
AAV
Acceso en línea:https://doaj.org/article/c447a4e33b7344ddb7f816064af2a6e0
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